Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides most of the energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.
Mary Frances "Debbie" Reynolds (April 1, 1932 – December 28, 2016) was an American actress, singer, businesswoman, film historian, and humanitarian. She was nominated for the Golden Globe Award for Most Promising Newcomer for her portrayal of Helen Kane in the 1950 film Three Little Words, and her breakout role was her first leading role, as Kathy Selden in Singin' in the Rain (1952). Other successes include The Affairs of Dobie Gillis (1953), Susan Slept Here (1954), Bundle of Joy (1956 Golden Globe nomination), The Catered Affair (1956 National Board of Review Best Supporting Actress Winner), and Tammy and the Bachelor (1957), in which her performance of the song "Tammy" reached number one on the Billboard music charts. In 1959, she released her first pop music album, titled Debbie.
Carrie Frances Fisher (October 21, 1956 – December 27, 2016) was an American actress, writer, and humorist. Fisher was the daughter of Eddie Fisher and Debbie Reynolds. She was known for playing Princess Leia in the Star Wars film series. Her other film roles included Shampoo (1975), The Blues Brothers (1980), Hannah and Her Sisters (1986), The 'Burbs (1989), and When Harry Met Sally... (1989).
Simon O. Sinek (born October 9, 1973) is a British/American author, speaker, and consultant. His 2009 book on personal development, Start With Why: How Great Leaders Inspire Everyone to Take Action (2009) delves into what he says is a naturally occurring pattern, grounded in the biology of human decision-making, that explains why we are inspired by some people, leaders, messages and organizations over others. He has commented for The New York Times, Wall Street Journal, The Washington Post, Houston Chronicle, FastCompany, CMO Magazine, NPR, and BusinessWeek, and was a regular contributor to The Huffington Post, BrandWeek, IncBizNet.
Gordon Edwynn Hunt (April 26, 1929 – December 17, 2016) was an American director, actor, producer and writer. He directed such animated productions as The Jetsons, Scooby-Doo, Super Friends, The Pirates of Dark Water, Droopy, Master Detective, Pound Puppies, The Richie Rich Show, The Smurfs and many more.
Helen Elizabeth Hunt (born June 15, 1963) is an American actress, film director, and screenwriter. She starred in the sitcom Mad About You for seven years, and played single mother Carol Connelly in the 1997 romantic comedy film As Good as It Gets, for which she won the Academy Award for Best Actress. Some of her other notable films include Twister (1996), Cast Away (2000), What Women Want (2000), Pay It Forward (2000), and The Sessions (2012), the latter garnered her a second Academy Award nomination. She made her directorial debut in 2007 with Then She Found Me (2007). Hunt has also won four Emmy Awards, four Golden Globe Awards, and two Screen Actors Guild Awards.
Snow White and the Seven Dwarfs is a 1937 American animated musical fantasy film produced by Walt Disney Productions and originally released by RKO Radio Pictures. Based on the German fairy tale by the Brothers Grimm, it is the first full-length cel animated feature film and the earliest Disney animated feature film. The story was adapted by storyboard artists Dorothy Ann Blank, Richard Creedon, Merrill De Maris, Otto Englander, Earl Hurd, Dick Rickard, Ted Sears and Webb Smith. David Hand was the supervising director, while William Cottrell, Wilfred Jackson, Larry Morey, Perce Pearce, and Ben Sharpsteen directed the film's individual sequences.
Zsa Zsa Gabor (February 6, 1917 – December 18, 2016) was a Hungarian-born American actress and socialite. Her sisters were actresses Eva and Magda Gabor. Gabor began her stage career in Vienna and was crowned Miss Hungary in 1936. She emigrated from Hungary to the United States in 1941 and became a sought-after actress with "European flair and style" and was considered to have a personality that "exuded charm and grace". Her first film role was a supporting role in Lovely to Look At. She later acted in We're Not Married! and played one of her few leading roles in the John Huston-directed film, Moulin Rouge (1952). Huston would later describe her as a "creditable" actress.
On the evening of 10 December 2016, two explosions caused by a car bombing and suicide bombing in Istanbul's Beşiktaş municipality killed 46 people and injured 166 others. 36 of the victims were police officers, 8 were civilians and one remains unidentified. 19 of the injured remain in critical condition. The Kurdistan Freedom Falcons (TAK) assumed responsibility, claiming that their members killed more than 100 police officers. TAK is a Kurdish nationalist militant group in Turkey seeking an independent Kurdish state in eastern and southeastern Turkey.
Red Hot Chili Peppers, also sometimes shortened to "The Chili Peppers" or abbreviated as "RHCP", are an American funk rock band formed in Los Angeles in 1983. The group's musical style primarily consists of rock with an emphasis on funk, as well as elements from other genres such as punk rock and psychedelic rock. When played live, their music incorporates elements of jam band due to the improvised nature of much of their performances. Currently, the band consists of founding members vocalist Anthony Kiedis and bassist Flea, longtime drummer Chad Smith, and former touring guitarist Josh Klinghoffer. Red Hot Chili Peppers are one of the best-selling bands of all time with over 80 million records sold worldwide, have been nominated for sixteen Grammy Awards, of which they have won six, and are the most successful band in alternative rock radio history, currently holding the records for most number-one singles (13), most cumulative weeks at number one (85) and most top-ten songs (25) on the Billboard Alternative Songs chart. In 2012, they were inducted into the Rock and Roll Hall of Fame.